The game mixes western and Japanese-themed comedy, containing over-the-top characters and storyline events. God Hand's plot follows Gene, a martial artist protecting his companion and wielding a legendary pair of divine arms called 'God Hands', in order to save the world from demons. It was re-released for the PlayStation 3 as a 'PS2 Classics' downloadable game on the PlayStation Network on October 4, 2011.

It was directed by Shinji Mikami, and was released in Japan and North America in 2006, and in 2007 for PAL territories. God Hand ( ゴッドハンド, Goddo Hando ?) is a 3D beat 'em up game developed by Clover Studio and published by Capcom for the PlayStation 2.